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Target intelligence / Profile preview
Gamma-aminobutyric acid receptor subunit alpha 5 (GABRA5)
- Target
- GABRA5
- Molecular classification
- Ligand-gated ion channel, Receptor, GABA-A receptor subunit
01
Overview
Gamma-aminobutyric acid receptor subunit alpha 5 (GABRA5) is a subunit of the GABA-A receptor, a ligand-gated chloride channel that mediates inhibitory neurotransmission in the brain. GABRA5-containing receptors are primarily found in the hippocampus and play roles in learning, memory, and anxiety. Selective modulation of GABRA5 receptors is being explored as a potential therapeutic strategy for cognitive disorders.
- Other names
- GABA-A receptor subunit alpha 5
02
Mechanism of action
Allosteric modulation of GABA-A receptor activity; either positive (agonists) or negative (inverse agonists)
03
Biological functions
Inhibitory neurotransmissionChloride transmembrane transportAssociative learningBehavioral fear responseSynaptic transmission
04
Disease associations
EpilepsyAddiction disordersSleep disturbancesCognitive impairmentAlzheimer's diseaseDown syndrome
05
Safety considerations
AmnesiaSedationPotential for pro-convulsant effects (with antagonists/inverse agonists in certain contexts)Off-target effects due to GABA-A receptor heterogeneity
06
Interacting drugs
alpha₅IA
8 more in the full profile.
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