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Target intelligence / Profile preview
Gamma-aminobutyric acid receptor subunit alpha-6 (GABRA6)
- Target
- GABRA6
- Molecular classification
- Ligand-gated ion channel, Receptor, GABA-A receptor subunit
01
Overview
Gamma-aminobutyric acid receptor subunit alpha-6 (GABRA6) is a protein that forms part of the GABA-A receptor, a ligand-gated chloride channel and one of the primary mediators of inhibitory neurotransmission in the mammalian central nervous system. α6-containing GABA-A receptors are essential for precise timing in motor activity and are implicated in neuropsychiatric disorders and other neurological conditions. Drugs targeting this specific subtype may offer new avenues for treating certain movement disorders or psychiatric conditions.
- Other names
- GABA(A) receptor subunit alpha-6GABAAR subunit alpha-6
02
Mechanism of action
Allosteric modulation of chloride conductance
03
Biological functions
Inhibitory neurotransmissionChloride ion transportMotor controlCognitive processingEmotional regulationSensory filtering
04
Disease associations
Neuropsychiatric disordersStress-associated conditionsEssential tremorMotor disturbances (Angelman syndrome, Down syndrome)Migraine
05
Safety considerations
Potential for side effects associated with broader-spectrum GABA-A receptor modulatorsRisk of tolerance and dependence with chronic benzodiazepine use
06
Interacting drugs
Benzodiazepines
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