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Target intelligence / Profile preview
Gamma-aminobutyric acid receptor subunit delta (GABRD)
- Target
- GABRD
- Molecular classification
- Receptor, Ion channel, Ligand-gated ion channel
01
Overview
The gamma-aminobutyric acid receptor subunit delta (GABRD) is a protein that forms part of the heteropentameric GABA_A receptors, which are ligand-gated chloride channels activated by gamma-aminobutyric acid (GABA). Delta-containing GABA_A receptors mediate tonic inhibition, regulating neuronal excitability. They exhibit distinct pharmacology compared to synaptically localized receptors, showing high sensitivity to neurosteroids and ethanol, and low efficacy for direct activation by GABA. Mutations in GABRD have been associated with generalized epilepsy with febrile seizures type 5.
- Other names
- Gamma-Aminobutyric Acid Type A Receptor Subunit DeltaGABAA receptor delta subunitDelta-GABAA receptor
02
Mechanism of action
Forms part of heteropentameric GABA_A receptors, ligand-gated chloride channels activated by GABA, mediating tonic inhibition and regulating neuronal excitability.
03
Biological functions
Chloride channel activityTonic InhibitionSynaptic Plasticity & MemorySignal Transduction
04
Disease associations
Generalized epilepsy with febrile seizures type 5Disorders involving altered neuronal excitability
05
Safety considerations
Altered neuronal excitabilityPotential interactions with neurosteroids, ethanol, and anesthetics
06
Interacting drugs
Neurosteroids
3 more in the full profile.
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