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Gamma-aminobutyric acid receptor subunit gamma
- Molecular classification
- Ligand-gated ion channel, Receptor
01
Overview
The gamma-aminobutyric acid (GABA) receptor subunit gamma is a component of the GABAA receptor, the primary inhibitory neurotransmitter receptor in the mammalian brain. It is a ligand-gated ion channel that mediates fast synaptic inhibition via chloride ion influx. The presence of the gamma subunit influences benzodiazepine binding and overall receptor function. Mutations are linked to neurological disorders like epilepsy.
- Other names
- GABA(A) receptor gamma-2GABA(A)R γ2
02
Mechanism of action
Enhances GABA-mediated chloride ion influx
03
Biological functions
Synaptic inhibitionNeurotransmission
04
Disease associations
EpilepsyFebrile seizuresDepressionNeurodevelopmental disorders
05
Safety considerations
ToleranceDependenceRespiratory depression
06
Interacting drugs
Benzodiazepines
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