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Target intelligence / Profile preview
Gamma-aminobutyric Acid Reuptake Transporter (None)
- Target
- None
- Molecular classification
- Transporter, Solute Carrier Family SLC6
01
Overview
Gamma-aminobutyric acid (GABA) reuptake transporters are membrane proteins responsible for the active transport of GABA, the primary inhibitory neurotransmitter in the central nervous system (CNS), from the extracellular space back into neurons and glial cells. This process is essential for terminating GABAergic synaptic transmission and maintaining low extracellular GABA concentrations.
02
Mechanism of action
Selective inhibitors to enhance inhibitory tone by increasing ambient extracellular levels of GABA.
03
Biological functions
Regulation/removal/recycling of extracellular GABA during synaptic transmissionNeurotransmitter transportTermination of synaptic transmission
04
Disease associations
EpilepsySeizure disordersAnxiety disordersSchizophreniaNeuropsychiatric conditions
05
Interacting drugs
Tiagabine
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