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Target intelligence / Profile preview
Gamma-Aminobutyric Acid Transmission (GABA)
- Target
- GABA
- Molecular classification
- Neurotransmitter system, Ligand-gated ion channel (GABAA), G protein-coupled receptor (GABAB), Enzyme (GAD, GAT, GABA transaminase), Transporter (GAT)
01
Overview
GABA transmission is the process by which gamma-aminobutyric acid (GABA), the primary inhibitory neurotransmitter in the mammalian central nervous system, mediates its effects. This involves GABA synthesis, release, receptor binding (GABAA and GABAB), and subsequent neuronal inhibition, playing a crucial role in regulating neuronal excitability and preventing overstimulation of the nervous system. Dysregulation of GABA transmission is implicated in various neurological and psychiatric disorders, making it a target for therapeutic intervention.
- Other names
- GABAergic neurotransmissionGABA systemGABA signaling
02
Mechanism of action
Enhancement or mimicry of GABA's inhibitory effects via various mechanisms including positive allosteric modulation of GABA receptors, GABA receptor agonism, or increasing GABA levels/efficacy.
03
Biological functions
Inhibitory neurotransmissionNeuronal excitability modulationSynaptic inhibitionTonic inhibitionDevelopmental regulation of neuronal activity
04
Disease associations
EpilepsyAnxiety disordersSchizophreniaFragile X syndromeRett syndromeDravet syndromeNeurological disorders
05
Safety considerations
SedationRespiratory depressionToleranceDependenceWithdrawal symptomsDevelopmental abnormalities
06
Interacting drugs
Benzodiazepines
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