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Gamma-aminobutyric acid transporter 1 (GAT1)
- Target
- GAT1
- Molecular classification
- Transporter, Solute carrier family 6 (SLC6)
01
Overview
Gamma-aminobutyric acid transporter 1 (GAT1) is a membrane protein responsible for the reuptake of gamma-aminobutyric acid (GABA) from the synaptic cleft into presynaptic neurons and astrocytes. It plays a critical role in regulating extracellular GABA levels, thereby controlling neuronal excitability and preventing excessive neuronal firing. Mutations or dysfunctions in GAT1 have been implicated in neurological disorders such as epilepsy.
- Other names
- Sodium- and chloride-dependent GABA transporter 1SLC6A1
02
Mechanism of action
Inhibition of GABA reuptake
03
Biological functions
GABA reuptakeRegulation of synaptic GABA concentrationTermination of inhibitory neurotransmissionRegulation of neuronal excitability
04
Disease associations
EpilepsyNeurodevelopmental disorders
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