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Gamma-Aminobutyric Acid Transporter 4 (GAT4)
- Target
- GAT4
- Molecular classification
- Transporter, Neurotransmitter:sodium symporter family
01
Overview
Gamma-aminobutyric acid transporter 4 (GAT4) is a member of the neurotransmitter:sodium symporter family, responsible for the reuptake of gamma-aminobutyric acid (GABA), the primary inhibitory neurotransmitter in the central nervous system. It is primarily studied in rodents, and while there isn't a direct human ortholog named 'GAT4', BGT1/SLC6A12 may serve a similar function. GAT4 plays a crucial role in regulating extracellular GABA concentrations and thus modulates synaptic transmission and neuronal excitability. It differs from other GATs in its neuronal-specific localization and substrate specificity, including β-alanine. Disruption can lead to imbalances in neural inhibition, potentially contributing to neurological disorders.
- Other names
- Gat4GABA transporter 4
02
Mechanism of action
Inhibition of GABA reuptake
03
Biological functions
Neurotransmitter reuptakeRegulation of extracellular GABA concentrationModulation of synaptic transmissionRegulation of neuronal excitability
04
Disease associations
Neurological disorders (related to imbalance between excitation and inhibition)
05
Safety considerations
Potential for seizures due to excessive inhibition if completely blocked
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