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Gamma-Aminobutyric Acid Transporter Type 1 (GAT1)
- Target
- GAT1
- Molecular classification
- Transporter, Solute Carrier Family 6 (SLC6), Neurotransmitter:Sodium Symporter
01
Overview
GABA transporter type 1 (GAT1) is a membrane protein responsible for the reuptake of gamma-aminobutyric acid (GABA), the primary inhibitory neurotransmitter in the mammalian central nervous system. It plays a crucial role in terminating synaptic transmission and maintaining extracellular GABA homeostasis. GAT1 is predominantly expressed in neurons, especially within presynaptic terminals, but also in certain glial cells. Inhibitors of GAT1 are used therapeutically for epilepsy management. Mutations or dysregulation are implicated in neurological disorders including epilepsy.
- Other names
- GABA transporter type 1SLC6A1
02
Mechanism of action
Inhibition of GABA reuptake, increasing synaptic and extracellular GABA concentrations
03
Biological functions
Neurotransmitter reuptakeRegulation of synaptic transmissionMaintenance of extracellular GABA homeostasisRegulation of inhibitory tone
04
Disease associations
EpilepsyNeurological disorders
05
Interacting drugs
Nipecotic acid
1 more in the full profile.
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