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Target intelligence / Profile preview
Gamma-aminobutyric acid type A receptor alpha 2 subunit (GABRA2)
- Target
- GABRA2
- Molecular classification
- Ligand-gated ion channel, Receptor
01
Overview
The gamma-aminobutyric acid type A receptor alpha 2 subunit (GABRA2) is a protein that forms part of the GABA-A receptor, a ligand-gated chloride channel activated by GABA, the principal inhibitory neurotransmitter in the mammalian central nervous system. Alpha-2 containing GABA-A receptors play key roles in emotional regulation, behavioral control, and mediation of anxiolytic effects. Alterations or mutations in GABRA2 have been linked to alcoholism, anxiety disorders, depression, drug dependence, and schizophrenia.
- Other names
- GABA(A) receptor subunit alpha-2GABAAR subunit alpha-2
02
Mechanism of action
Allosteric modulation of chloride channel opening frequency and duration
03
Biological functions
NeurotransmissionSynaptic inhibitionEmotional regulationBehavioral controlAnxiolytic effects
04
Disease associations
AlcoholismAnxiety disordersDepressionDrug dependence (ethanol, nicotine, cannabis)SchizophreniaPain
05
Safety considerations
SedationToleranceDependenceRespiratory depressionPotential for abuse
06
Interacting drugs
Benzodiazepines
4 more in the full profile.
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