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Target intelligence / Profile preview
Gamma-Aminobutyric Acid Type A Receptor Alpha1 Subunit (GABRA1)
- Target
- GABRA1
- Molecular classification
- Ligand-gated ion channel, Cys-loop superfamily, Receptor
01
Overview
The gamma-aminobutyric acid type A receptor alpha1 subunit (GABRA1) is a protein subunit of the GABA_A receptor, a ligand-gated chloride channel responsible for mediating fast synaptic inhibition in the central nervous system. It is a key target for benzodiazepines and Z-drugs, which enhance GABAergic neurotransmission and produce sedative, anxiolytic, and muscle-relaxant effects. Mutations or dysfunctions in GABRA1 are associated with neurological disorders, particularly epilepsy syndromes.
- Other names
- GABA A receptor alpha1 subunitGABRA1 protein
02
Mechanism of action
Allosteric modulation of GABA_A receptor chloride conductance; increased frequency of channel opening (benzodiazepines) or selective agonism at alpha1 subunit-containing GABA_A receptors (Z-drugs)
03
Biological functions
Synaptic inhibitionNeurotransmissionRegulation of neuronal excitabilityModulation of anxietyRegulation of sleep-wake cyclesMuscle relaxationMemory formation/modulation
04
Disease associations
EpilepsyChildhood absence epilepsyNeurological disorders
05
Safety considerations
ToleranceDependenceWithdrawal symptomsCognitive impairmentRespiratory depression
06
Interacting drugs
Benzodiazepines
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