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Gamma-aminobutyric acid type A receptor alpha2 subunit (GABRA2)
- Target
- GABRA2
- Molecular classification
- Ligand-gated ion channel, Cys-loop receptor, GABA-A receptor subunit
01
Overview
Gamma-aminobutyric acid type A receptor alpha2 subunit (GABRA2) is a protein subunit of the GABA-A receptor, a ligand-gated chloride channel. Activation by GABA leads to chloride influx, hyperpolarization, and reduced neuronal excitability. GABRA2 contributes to the receptor's pharmacological properties, including benzodiazepine binding affinity and is implicated in various neuropsychiatric disorders like anxiety, depression, alcoholism, and schizophrenia.
- Other names
- Gamma-aminobutyric acid receptor subunit alpha-twoGabra-two
02
Mechanism of action
Binding to the GABA-A receptor, enhancing GABA-induced chloride ion influx, leading to hyperpolarization and reduced neuronal excitability.
03
Biological functions
Mediates fast synaptic inhibitionChloride ion transmembrane transportRegulation of neuronal excitability
04
Disease associations
Anxiety disordersDepressionAlcoholismDrug dependenceSchizophrenia
05
Interacting drugs
Benzodiazepines
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