Gamma-aminobutyric acid type A receptor alpha4 subunit (GABRA4)

The gamma-aminobutyric acid type A receptor alpha4 subunit (GABRA4) is a protein subunit of the GABA_A receptor, a ligand-gated ion channel that mediates inhibitory neurotransmission in the central nervous system. Alpha4-containing receptors are predominantly located extrasynaptically and contribute to tonic inhibition, playing a critical role in regulating neuronal excitability, particularly in the thalamus and dentate gyrus. These receptors are relatively insensitive to benzodiazepines but sensitive to other sedative-hypnotics like neurosteroids and gaboxadol. GABRA4 has been implicated in autism spectrum disorders.

Other names

GABA(A) receptor subunit alpha-4GABAAR subunit alpha-4

Forms part of GABA_A receptors that mediate inhibitory neurotransmission by allowing chloride ions to flow into neurons upon activation by gamma aminobutyric acid (GABA), leading to hyperpolarization. Predominantly involved in tonic inhibition through extrasynaptic receptors.