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Target intelligence / Profile preview
Gamma-Aminobutyric Acid Type A Receptor Subunit Alpha-3 (GABRA3)
- Target
- GABRA3
- Molecular classification
- Receptor, Ion channel, Ligand-gated ion channel
01
Overview
Gamma-aminobutyric acid A receptor subunit alpha-3 (GABRA3) is a protein that forms part of the GABA\(_{A}\) receptor, a heteropentameric ligand-gated chloride channel. This receptor is activated by gamma-aminobutyric acid (GABA), which is the major inhibitory neurotransmitter in the vertebrate brain. Upon GABA binding, the channel opens to allow chloride ions to flow into neurons, leading to hyperpolarization and inhibition of neuronal activity. GABRA3-containing receptors are implicated in various physiological processes including modulation of anxiety, sleep regulation, muscle relaxation, and seizure susceptibility due to their inhibitory action on neuronal firing. Alterations or dysregulation involving GABRA3 have been associated with autism spectrum disorder and hepatocellular carcinoma.
- Other names
- Gamma-Aminobutyric Acid Type A Receptor Subunit Alpha-3GBRA3 ProteinGABA(A) Receptor Subunit Alpha-3
02
Mechanism of action
GABA binding leads to chloride ion influx, hyperpolarization, and inhibition of neuronal activity.
03
Biological functions
Transmitter-gated monoatomic ion channel activityRegulation of postsynaptic membrane potentialFast synaptic inhibitionChloride ion influx
04
Disease associations
Autism spectrum disorderHepatocellular carcinoma
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