Gamma-aminobutyric acid type B receptor subunit 1

Gamma-aminobutyric acid type B receptor subunit 1 (GABBR1) is a protein that forms part of the GABA_B receptor, a G-protein coupled receptor (GPCR) for GABA, the main inhibitory neurotransmitter in the mammalian central nervous system. The functional GABA_B receptor operates as an obligate heterodimer with GABBR2. Variants or dysfunctions in this gene have been linked to several neurodevelopmental disorders including neurodevelopmental disorder with language delay and intellectual disability. Susceptibility loci for multiple sclerosis, epilepsy, schizophrenia—and possibly other neuropsychiatric conditions—have been mapped near or within this region on chromosome 6p21.3 where GABBR1 resides.

Other names

GABBR1hGB1aGPRC3Agamma aminobutyric acid (GABA) B receptor 1

Activation of inwardly rectifying potassium channels, leading to hyperpolarization of neurons and inhibition of neurotransmitter release