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Target intelligence / Profile preview
Gamma Aminobutyric Acid Type C Receptor (GABAC receptor)
- Target
- GABAC receptor
- Molecular classification
- Ligand-gated ion channel, Ionotropic receptor, Receptor
01
Overview
The GABAC receptor is a member of the ligand-gated ion channel superfamily and is primarily known as a chloride-permeable ionotropic gamma-aminobutyric acid (GABA) receptor. It is distinct from the more widely distributed GABAA and metabotropic GABAB receptors, both in structure and pharmacology. The functional GABAC receptor is typically a pentamer composed mainly of rho (ρ) subunits: ρ1, ρ2, and ρ3. It mediates inhibitory neurotransmission via chloride influx leading to hyperpolarization of neurons. It plays unique roles in retinal circuitry through mechanisms such as slow activation kinetics, segregation from other inhibitory receptors, and participation in multi-neuronal pathways.
- Other names
- GABA(A)-rho receptorGABA(ρ) receptor
02
Mechanism of action
Chloride ion influx
03
Biological functions
Inhibitory neurotransmissionNeuronal hyperpolarizationVisual signal processing
04
Disease associations
Visual processing disordersEpilepsy
05
Safety considerations
Selective modulation of inhibitory signaling is required to avoid affecting classical fast synaptic inhibition.
06
Interacting drugs
GABA
7 more in the full profile.
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