Gamma-crystallin B (CRYGB)

Gamma-crystallin B is a highly stable, water-soluble, monomeric protein encoded by the CRYGB gene in humans and is a dominant structural component of the vertebrate eye lens[1][2][5][6]. It belongs to the beta/gamma-crystallin protein superfamily and plays a crucial role in maintaining lens transparency and the lens’s refractive properties[1][2][6]. Unlike other crystallins, gamma-crystallins such as CRYGB typically lack connecting peptides and terminal extensions, and they are differentially regulated after early development[1]. Mutations or age-related changes in gamma-crystallins, including CRYGB, can lead to lens opacification and cataract formation, but CRYGB is not considered a classical therapeutic target such as a receptor, enzyme, or transporter[1][5][6].

Other names

Gamma-crystallin BCRYGBCRYG2Gamma-B-crystallinGamma-crystallin 1-2CTRCT39crystallin gamma Bgamma-crystallin Bcrystallin, gamma 1-2