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Target intelligence / Profile preview
Gamma Globin Gene
- Molecular classification
- Gene, Hemoglobin subunit
01
Overview
The gamma globin gene (HBG1/HBG2) encodes the gamma subunits of fetal hemoglobin (HbF). HbF is the predominant hemoglobin in fetuses and newborns, playing a key role in oxygen transport. Reactivation or upregulation of gamma globin expression is a therapeutic strategy for treating sickle cell disease and beta-thalassemia.
- Other names
- HBG1HBG2HGB-T2HBGAHBGRHSGGL1PRO2979
02
Mechanism of action
Upregulation of gamma globin expression
03
Biological functions
Oxygen transportFetal hemoglobin production
04
Disease associations
Sickle cell diseaseBeta-thalassemiaHereditary persistence of fetal hemoglobin (HPFH)
05
Safety considerations
Potential for off-target effects in gene editing approachesUnpredictable effects of long-term HbF elevation
06
Biomarkers
HbF levelsHBG1/HBG2 gene expression
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