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Target intelligence / Profile preview
Gamma-glutamyl transferase (GGT)
- Target
- GGT
- Molecular classification
- Enzyme
01
Overview
Gamma-glutamyl transferase (GGT) is a widely distributed membrane-associated enzyme essential for maintaining cellular redox balance through glutathione metabolism while serving clinically both as a sensitive marker for hepatobiliary injury/dysfunction and increasingly recognized indicator across diverse systemic pathologies including cardiovascular/metabolic/cancerous conditions.
- Other names
- Gamma-glutamyl transpeptidaseγ-glutamyltransferaseGGTP
02
Mechanism of action
Inhibition of GGT activity to modulate glutathione metabolism, amino acid transport, and inflammatory signaling
03
Biological functions
Glutathione metabolismAmino acid transportDrug detoxificationXenobiotic detoxificationRedox balanceInflammatory signalingNitric oxide pathway regulation
04
Disease associations
Liver dysfunctionBile duct obstructionLiver diseaseNonalcoholic fatty liver diseaseCardiovascular diseasesArterial stiffness/AtherosclerosisDiabetes mellitusGestational diabetesCancerInfectious diseasesDementia
05
Safety considerations
Elevated GGT lacks specificity for particular etiologies because it can be induced by various drugs or conditions unrelated to direct tissue damage
06
Biomarkers
Serum GGT levels
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