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Gamma-glutamylamine cyclotransferase (GGACT)

Target: GGACT
Molecular classification: Enzyme

Overview

Gamma-glutamylamine cyclotransferase (GGACT) is an enzyme that catalyzes the conversion of gamma-glutamylamines—specifically gamma-glutamyl-epsilon-lysine, which results from the breakdown of proteins cross-linked by transglutaminases—into free amines and 5-oxoproline. The enzyme contributes to the degradation of cross-linked proteins by breaking the isopeptide bond between lysine and glutamic acid residues. GGACT adopts a cyclotransferase fold similar to gamma-glutamylcyclotransferase (GGCT), but with substrate specificity for gamma-glutamylamines rather than gamma-glutamyl-alpha-amino acids

Other names: Gamma-glutamylamine cyclotransferaseGGACTA2LD1AIG2-like domain-containing protein 1Gamma-glutamylaminecyclotransferaseAIG2-like domain 1

Biological functions

Protein cross-link degradationGamma-glutamyl-epsilon-lysine catabolismAmino acid metabolism

Disease associations

Other (Potential role in diseases related to abnormal protein cross-linking or amino acid metabolism, not specifically linked to major disease categories like cancer or neurodegeneration in available sources)

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