Gamma-glutamyltransferase 3 pseudogene (GGT3P)

Gamma-glutamyltransferase 3 pseudogene (GGT3P) is a human gene classified as a pseudogene, meaning it has a similar sequence to gamma-glutamyltransferase family genes but is not translated into a functional enzyme or protein. It is located on chromosome 22 and is annotated based on sequence homology to potentially enable glutathione hydrolase activity and participate in peptide modifications and the glutathione catabolic process; however, these are predicted bioinformatically, not demonstrated experimentally. GGT3P does not have a known biological function, does not encode an active protein, is not a therapeutic target, and is commonly misidentified due to similarity in name to active gamma-glutamyltransferases involved in glutathione metabolism and drug detoxification. Key clarification: The confusion often arises because the gamma-glutamyltransferase family includes several functional enzymes (e.g., GGT1) that play important biological and clinical roles, but GGT3P is a non-coding, non-functional pseudogene.

Other names

Putative glutathione hydrolase 3 proenzymePutative glutathione hydrolase 3 heavy chainPutative glutathione hydrolase 3 light chainGGT3PGGT3GGT 3Gamma-glutamyltransferase 3Putative gamma-glutamyltranspeptidase 3Inactive gamma-glutamyltranspeptidase 2

Not applicable for GGT3P as it is not a drug target or functional molecule