Gamma-glutamyltransferase family pseudogene

This entry represents a **gamma-glutamyltransferase family pseudogene**, a non-functional genomic sequence related to members of the gamma-glutamyltransferase enzyme family. Unlike active GGT enzymes, this pseudogene does not encode a protein product and thus does not participate in glutathione metabolism, amino acid transport, or any known physiological process. The GGT gene family includes several functional isoforms (such as GGT1, GGT5, GGT6, and GGT7) that are critical for glutathione metabolism and drug detoxification, and also multiple pseudogenes (such as GGT2P, GGT3P, GGT4P, GGT8P) that are considered non-functional[2][3][5][6][7]. Pseudogenes can arise via gene duplication or retrotransposition and usually accumulate mutations that disable protein coding. The gamma-glutamyltransferase family pseudogene ENSG00000236168 is such a pseudogene, and there is no established evidence for biological activity, disease relevance, or druggability.

Other names

Gamma-glutamyltransferase pseudogeneGGT pseudogene