Gamma-glutamyltransferase light chain 1 (GGTLC1)

Gamma-glutamyltransferase light chain 1 (GGTLC1) is a protein encoded by the GGTLC1 gene. It is a member of the gamma-glutamyl transpeptidase (GGT) family but is distinct from the better-studied GGT1 enzyme. GGTLC1 contains homology to the light chain region of canonical GGT enzymes but lacks a transmembrane domain and the full enzymatic activity found in classical GGTs. Its function is incompletely understood; Gene Ontology descriptions list its gamma-glutamyltransferase activity as "obsolete," and its characterized physiological roles and interacting drugs remain unknown. Disease associations are limited, with possible links to glutathionuria, but no direct evidence establishes it as a therapeutic target. Key context: - GGTLC1 is not the canonical gamma-glutamyltransferase 1 (GGT1) enzyme, which is well-characterized and therapeutically relevant as a biomarker and in glutathione metabolism. - The protein encoded by GGTLC1 is more limited in function, with uncertain or non-established enzymatic activity. - Multiple aliases exist because of historical naming in different studies; however, GGTLC1 is specific and not the main enzymatic target in this gene family. - There are no drugs, mechanisms of action, or biomarker data associated with GGTLC1. Note: This target is frequently confused with "gamma-glutamyltransferase 1" (GGT1), which *is* a validated enzyme and significant therapeutic target involved in glutathione metabolism, drug resistance in cancer, and is a clinical biomarker. Your target, however, is GGTLC1, which does not currently fit these criteria, and its therapeutic relevance is not established.

Other names

Glutathione hydrolase light chain 1GGTLA3GGTLA4dJ831C21.1dJ831C21.2GGTL6gamma-glutamyltransferase-like activity 3gamma-glutamyltransferase-like activity 4gamma-glutamyltransferase-like protein 6