Gamma-glutamyltransferase light chain family member 3 (GGTLC3)

Gamma-glutamyltransferase light chain family member 3 (GGTLC3) is a member of the gamma-glutamyltransferase (GGT) family, which includes enzymes responsible for cleaving gamma-glutamyl peptide bonds in glutathione and other peptides[1][4]. Unlike canonical GGT1, GGTLC3 contains a region homologous to the light chain subunit of GGT but lacks the heavy chain necessary for membrane anchoring and typical enzymatic activity[1][4]. As such, GGTLC3 is considered a "light chain-only" member of this family and is of uncertain or *putative* glutathione hydrolase function. While there is evidence for the involvement of canonical GGTs in glutathione metabolism, drug detoxification, and roles in certain diseases, there are currently no validated drug interactions, direct disease associations, or established roles for GGTLC3 in human physiology or as a therapeutic target[4][1][5][6]. GGTLC3 is predicted to have glutathione hydrolase activity and possible involvement in leukotriene metabolism, but this is not experimentally validated[6][4]. The gene is cataloged on chromosome 22, and its dysfunction has been reported in genetic association datasets related to rare diseases such as glutathionuria and some types of cataracts[4]. No specific biomarkers, therapeutic implications, or significant safety concerns have been established for GGTLC3 in clinical or pharmacological contexts[1][4][6].

Other names

Glutathione hydrolase light chain 3GGTLC3Gamma-glutamyltransferase light chain 3putative gamma-glutamyltransferase light chain 3putative glutathione hydrolase light chain 3GGTL3_HUMAN