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Target intelligence / Profile preview
Staphylococcus gamma-hemolysin AB (HlgAB)
- Target
- HlgAB
- Molecular classification
- Pore-forming toxin, Bicomponent toxin
01
Overview
Staphylococcus gamma-hemolysin AB (HlgAB) is a bicomponent, pore-forming toxin produced by Staphylococcus aureus. It is composed of HlgA and HlgB subunits that oligomerize on the surface of target cells, forming a transmembrane pore that leads to cell lysis. HlgAB targets chemokine receptors CXCR1, CXCR2, and CCR2 on immune cells, particularly neutrophils and monocytes, contributing to immune evasion during S. aureus infection.
- Other names
- HlgAB toxinGamma-hemolysin ABγ-hemolysin AB
02
Mechanism of action
Forms a pore in the cell membrane of target cells, leading to cell lysis.
03
Biological functions
Immune evasionCell lysisLeukocyte killingMembrane disruption
04
Disease associations
InfectionStaphylococcus aureus pathogenesisBacteremia
05
Safety considerations
Potential for off-target effects due to pore-forming activity.Contribution to S. aureus virulence and disease severity.
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