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Target intelligence / Profile preview
Staphylococcus gamma-hemolysin CB (HlgCB)
- Target
- HlgCB
- Molecular classification
- Toxin, Pore-forming toxin, Bicomponent toxin
01
Overview
Staphylococcus gamma-hemolysin CB (HlgCB) is a bicomponent, pore-forming toxin produced by Staphylococcus aureus. It comprises HlgC and HlgB subunits, which assemble to form a functional toxin that targets human complement receptors C5aR (CD88) and C5L2 on phagocytic cells like neutrophils and monocytes, leading to cell lysis. HlgCB contributes to S. aureus virulence by impairing innate immune responses. Its expression varies among clinical isolates due to differences in gene regulation.
- Other names
- HIgCBGamma-Hemolysin CBHlgC + HlgBHlgCB toxin
02
Mechanism of action
Oligomerization on target membrane, formation of cation-selective pores, cell lysis
03
Biological functions
Cell lysisImmune evasionPore formationReceptor bindingPhagocyte destruction
04
Disease associations
InfectionStaphylococcus aureus infectionsInflammation
05
Safety considerations
Non-specific toxicityPotential for off-target effectsImmune suppression
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