Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Gamma-hydroxybutyric acid receptor (None)
- Target
- None
- Molecular classification
- G protein-coupled receptor (GPCR), Receptor, Riboflavin transporter
01
Overview
The gamma-hydroxybutyric acid receptor (GHBR) is an excitatory G protein-coupled receptor that binds the endogenous neurotransmitter gamma-hydroxybutyric acid (GHB). It is distinct from the GABA_B receptor and mediates stimulant effects through increased Na+/K+ currents and neurotransmitter release. The receptor has approximately 11 transmembrane helices and is expressed in various brain regions, including the dentate gyrus, thalamus, and cerebellum. It plays a role in regulating neurotransmitter systems, sleep, mood, and anxiety.
- Other names
- GHB receptorGHBRGPR172ASLC52A2
02
Mechanism of action
Activation leads to increased Na+/K+ current and enhanced release of dopamine and glutamate, resulting in stimulant effects. May also enhance tryptophan transport and modulate oxytocinergic neuron activity.
03
Biological functions
NeurotransmissionSignal transductionTryptophan transportRegulation of sleepRegulation of moodRegulation of anxietyOxytocin neuron activationDopamine releaseGlutamate release
04
Disease associations
Anxiety disordersSleep disordersMood disordersEpilepsy (convulsions at high doses)
05
Safety considerations
High doses can cause convulsionsPotential for abuse due to psychoactive effects
06
Interacting drugs
Gamma-hydroxybutyric acid (GHB)
13 more in the full profile.
Beyond the preview
Go deeper on Gamma-hydroxybutyric acid receptor (None).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Gamma-hydroxybutyric acid receptor (None).