Gamma oscillation

Gamma oscillations are patterns of synchronized electrical activity between populations of neurons in the brain, manifesting in frequency bands of approximately 30–90 Hz (sometimes extended up to 150 Hz). They are considered crucial for coordination between brain areas, perception, attention, working memory, and other cognitive and behavioral processes. Their disruption is associated with a range of neuropsychiatric and neurodegenerative diseases, including Alzheimer’s disease, Parkinson’s disease, schizophrenia, epilepsy, and Fragile X syndrome. Gamma oscillations are generated by synchronized firing of neuronal groups, particularly involving inhibitory interneurons. While not a traditional “therapeutic target,” emerging research explores non-invasive strategies (like sensory or electrical stimulation at gamma frequencies) to restore gamma activity as a possible treatment for cognitive dysfunction in disorders such as Alzheimer’s disease.

Other names

Gamma waveGamma rhythmGamma brain wave

Non-pharmacological mechanisms include neural entrainment via sensory stimulation or brain stimulation techniques at gamma frequencies