Target intelligence / Profile preview

Gamma photon emission from indium‑111 (^111^In or In-111)

Target
^111^In or In-111
Molecular classification
Other — radioactive isotope, diagnostic radionuclide
01

Overview

Indium-111 is a radioactive isotope (^111^In) that decays by electron capture with a half-life of approximately 2.8 days (67–68 hours). During decay, it emits gamma photons (171.3 and 245.4 keV) that serve as the basis for diagnostic imaging procedures in nuclear medicine. Indium-111 can be used to label monoclonal antibodies, white blood cells, platelets, or small molecules, allowing targeted imaging of cancers, infections, inflammation, and certain neurologic indications. Indium-111 and its gamma photon emissions are critical for nuclear imaging but are not themselves molecular targets; rather, they are tools employed to visualize the distribution and trafficking of radiolabeled compounds or cells.

Other names
Indium In-111^111^InIndium-111 chlorideIndium-111 oxyquinolineIndium-111 pentetate
02

Mechanism of action

Decay by electron capture — resulting in emission of gamma photons (171 and 245 keV) which can be detected by gamma cameras (planar or SPECT)

03

Biological functions

Other — used as a radioactive tracer for imaging, does not participate in cellular signal transduction or biological regulation
04

Disease associations

Other — diagnostic imaging of cancerinfectioninflammationthrombuslocalization of tissues
05

Safety considerations

Radiation exposure and contamination riskHandling and shielding (lead) requirements due to gamma radiationToxicity generally low but must follow radiopharmaceutical safety protocols
06

Interacting drugs

Indium In-111 chloride

4 more in the full profile.

07

Biomarkers

Gamma photon emission itself is used as an imaging biomarker for localization of labeled cells or molecules; no direct patient stratification biomarker

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