Gamma-sarcoglycan protein (SGCG)

Gamma-sarcoglycan is a 35 kDa type II transmembrane glycoprotein expressed primarily in skeletal and cardiac muscle, encoded by the SGCG gene on chromosome 13. It is one of four main sarcoglycan subunits (alpha, beta, gamma, delta), forming a complex that stabilizes the dystrophin-associated protein complex in muscle cell membranes. This complex anchors muscle cell cytoskeleton to the extracellular matrix, ensuring structural integrity during contraction and relaxation. Mutations in SGCG disrupt the sarcoglycan complex, leading to autosomal recessive limb-girdle muscular dystrophy type 2C (LGMD2C), a progressive muscle-wasting disorder. Gamma-sarcoglycan is also involved in neuromuscular junction maintenance, but is not a classic therapeutic drug target (such as a receptor or enzyme)[1][3][4][5][7][10].

Other names

gamma sarcoglycangamma-sarcoglycangamma-SG35 kDa dystrophin-associated glycoprotein35DAGA4DMDADMDA1LGMD2CSCARMD2SCG3SG-gammaSGCG_HUMAN