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Target intelligence / Profile preview
Gamma-Secretase Enzyme Complex (γ-Secretase)
- Target
- γ-Secretase
- Molecular classification
- Enzyme, Aspartyl Protease, Multi-subunit protein complex, Intramembrane Protease
01
Overview
Gamma-secretase is a multi-subunit, integral membrane protease complex responsible for the intramembrane cleavage of various type I transmembrane proteins. It is best known for its role in processing amyloid precursor protein (APP) to generate amyloid-beta (Aβ) peptides, which are implicated in Alzheimer's disease pathology. The enzyme also cleaves other substrates such as Notch receptors, making it central to multiple signaling pathways and cellular processes. The complex consists of four essential protein subunits: Presenilin (PSEN1 or PSEN2), Nicastrin, APH-1 (Anterior Pharynx Defective 1), and PEN-2 (Presenilin Enhancer 2).
- Other names
- gamma secretaseγ secretasegamma-secretase
02
Mechanism of action
Inhibition of intramembrane proteolysis of target proteins such as APP and Notch.
03
Biological functions
ProteolysisIntramembrane cleavageAmyloid-beta (Aβ) productionNotch signaling pathway regulationRegulation of cell fateCardiovascular developmentImmune cell function
04
Disease associations
Familial Alzheimer’s diseaseAlzheimer's diseaseNeurodegenerative diseaseDevelopmental disordersCardiac disorders
05
Safety considerations
Broad inhibition can cause side effects due to interference with normal physiological functions beyond just APP/Aβ production.Inhibition of Notch signaling can lead to developmental and immunological problems.
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