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Target intelligence / Profile preview
Gamma-tubulin complex component 5 (TUBGCP5)
- Target
- TUBGCP5
- Molecular classification
- Other (centrosomal protein), Cytoskeletal protein, Microtubule-associated protein
01
Overview
Gamma-tubulin complex component 5 (TUBGCP5) is a protein-coding gene that encodes a component of the gamma-tubulin ring complex (γTuRC), which is critical for microtubule nucleation at the centrosome in human cells. This protein enables microtubule binding activity and is localized primarily to the centrosome, ciliary basal body, and cytosol. The gamma-tubulin ring complex is essential for the formation of functional microtubule organizing centers, thereby facilitating cell division, maintenance of cell structure, and ciliary function. TUBGCP5 plays important roles in cellular processes dependent on microtubule dynamics, with disease associations including autism spectrum disorder and dyscalculia, though it is not currently considered a common therapeutic target[1][2][3][5][7].
- Other names
- Gamma-tubulin complex component 5TUBGCP5GCP5KIAA1899GCP-5gamma-tubulin complex component GCP5tubulin gamma complex associated protein 5
02
Biological functions
Microtubule nucleationMicrotubule bindingOrganization of the centrosome and ciliary basal body
03
Disease associations
Autism spectrum disorderDyscalculia
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