Target intelligence / Profile preview

Gamma-tubulin complex component 6 (TUBGCP6)

Target
TUBGCP6
Molecular classification
Other (component of the gamma-tubulin ring complex)
01

Overview

Gamma-tubulin complex component 6 (TUBGCP6) is a protein encoded by the *TUBGCP6* gene that serves as a subunit of the gamma-tubulin ring complex (gTuRC), which is essential for microtubule nucleation at the centrosome[1][2][3][6][8]. This process is critical for organizing microtubules, facilitating centrosome duplication, and forming the mitotic spindle during cell division[1][8]. Mutations in this gene are associated with disorders such as microcephaly and chorioretinopathy[1][3]. There is no evidence that TUBGCP6 functions as a direct drug target or receptor, nor are there known drugs or mechanisms of action relevant to this molecule in the context of pharmacological targeting[1][8].

Other names
GCP6GCP-6KIAA1669DJ402G11.6tubulin gamma complex associated protein 6MCCRPMCCRP1MCPHCR
02

Biological functions

Microtubule nucleationCentrosome organizationCell cycle (mitosis spindle formation)
03

Disease associations

Microcephaly and chorioretinopathy (autosomal recessive disorder)Microcephaly

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