Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Ganciclovir Kinase
- Molecular classification
- Enzyme, Serine/threonine protein kinase
01
Overview
Ganciclovir kinase refers to viral or cellular kinases that phosphorylate the antiviral drug ganciclovir, converting it from a prodrug into its active form. The most clinically relevant ganciclovir kinase is the UL97 protein encoded by human cytomegalovirus (HCMV), which is a serine/threonine kinase responsible for the initial phosphorylation of ganciclovir. In herpes simplex virus (HSV), thymidine kinase (TK) performs this function. Mutations in these kinases can lead to ganciclovir resistance.
- Other names
- HCMV UL97 proteinUL97 kinaseHerpes simplex virus thymidine kinaseHSV thymidine kinase
02
Mechanism of action
Phosphorylation of ganciclovir to its monophosphate form, leading to downstream activation and inhibition of viral DNA polymerase.
03
Biological functions
Phosphorylation of nucleoside analogsDrug activationRegulation of viral replicationCell cycle regulation
04
Disease associations
InfectionHuman Cytomegalovirus (HCMV) infectionHerpes Simplex Virus (HSV) infectionDrug resistance
05
Safety considerations
Drug resistance due to mutations in the kinase domain.Dependence of ganciclovir activation on functional kinase expression.
06
Interacting drugs
Ganciclovir
1 more in the full profile.
Beyond the preview
Go deeper on Ganciclovir Kinase.
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Ganciclovir Kinase.