Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Ganglioside GD2 (None)
- Target
- None
- Molecular classification
- Disialoganglioside, Glycosphingolipid, Tumor-associated antigen
01
Overview
Ganglioside GD2 is a disialoganglioside highly expressed in tumors of neuroectodermal origin. It promotes tumorigenesis by enhancing cell survival, proliferation, motility, migration, adhesion, and invasion, and can contribute to immune evasion. GD2 is a target for immunotherapies like monoclonal antibodies, bispecific antibodies, and CAR-T cells. It also serves as a circulating biomarker for certain cancers.
02
Mechanism of action
Antibody-dependent cellular cytotoxicity (ADCC), Complement-dependent cytotoxicity (CDC), Direct induction of apoptosis/necrosis
03
Biological functions
Membrane microdomain formationSignal regulationCell survivalCell proliferationCell motilityCell migrationCell adhesionCell invasionImmune evasion
04
Disease associations
CancerNeuroblastomaMelanomaRetinoblastomaEwing sarcomaGliomasOsteosarcomaSmall cell lung cancerSoft tissue sarcomas
05
Safety considerations
Off-target effects due to low expression in normal tissuesOn-target, off-tumor toxicity
06
Interacting drugs
ch14.18 (dinutuximab)
6 more in the full profile.
07
Biomarkers
GD2 serum levelsGD2 expression on tumor cells
Beyond the preview
Go deeper on Ganglioside GD2 (None).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Ganglioside GD2 (None).