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Target intelligence / Profile preview
Ganglioside GM2
- Molecular classification
- Glycosphingolipid, Monosialo-ganglioside, Lipid
01
Overview
Ganglioside GM2 is a glycosphingolipid found in the outer leaflet of cell membranes. It plays roles in cell signaling, neuronal development, immune responses, and is implicated in lysosomal storage disorders and cancer. As a tumor-associated antigen, it is a target for cancer immunotherapy.
- Other names
- Tay–Sachs gangliosideβ-D-GalNAc-(1→4)-[α-Neu5Ac-(2→3)]-β-D-Gal-(1→4)-β-D-Glc-(1↔1)-N-octadecanoylsphingosine
02
Mechanism of action
Antibodies targeting GM2 have shown anti-tumor effects both experimentally and clinically.
03
Biological functions
Membrane organizationCell signalingNeuronal developmentImmune modulationCell adhesionSignal transduction
04
Disease associations
Tay-Sachs diseaseSandhoff diseaseAB variant diseaseCancerNeurodegenerative disease
05
Safety considerations
Potential off-target effects if not specifically targeted in immunotherapy; however, antibodies targeting GM2 have shown minimal toxicity related to off-target effects on healthy tissue in clinical trials.
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