Ganglioside-induced differentiation-associated protein 1-like 1 (GDAP1L1)

Ganglioside-induced differentiation-associated protein 1-like 1 (GDAP1L1) is a protein-coding gene in humans, closely related in sequence and domain organization to GDAP1, which regulates mitochondrial dynamics, especially fission, and is associated with the glutathione S-transferase superfamily[1][2][5][6]. GDAP1L1 is predicted to localize to the mitochondrial outer membrane and is expressed in various tissues, but specific biological functions, involvement in disease, drug interactions, and safety profiles are not currently characterized in the literature or major genetic databases[1][5][6][7][9]. Unlike GDAP1, which is a validated regulator of mitochondrial structure whose mutations cause Charcot-Marie-Tooth neuropathy, GDAP1L1 has not been confirmed as a therapeutic target or a disease gene[2][6][8][9]. Current research describes GDAP1L1 as an uncharacterized or putative mitochondrial protein, with molecular features strongly matching those of the GST family and potential—but unproven—roles in neural cell function[1][2][3][4][5][7].

Other names

Ganglioside-induced differentiation-associated protein 1-like 1GDAP1L1GDAP1-L1dJ881L22.1dJ995J12.1.1