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Target intelligence / Profile preview
Ganglioside N-glycolylneuraminic acid GM3 (NGcGM3)
- Target
- NGcGM3
- Molecular classification
- Glycosphingolipid, Ganglioside, Other (Tumor neoantigen)
01
Overview
NGcGM3 is a tumor-associated glycosphingolipid neoantigen present on diverse human cancers, not on normal tissues, enabling precise immunotherapy targeting.
- Other names
- GM3(Neu5Gc)N-glycolyl GM3N-glycolylneuraminic acid GM3NGc ganglioside GM3
02
Mechanism of action
Antibody-mediated cytotoxicity; CAR T cell lysis; Vaccine-induced immunity; Anti-angiogenesis
03
Biological functions
Cell signalingImmune modulationCell adhesion/migrationCell proliferation/differentiation/apoptosis
04
Disease associations
CancerImmune suppression in TMEOther (mainly cancer)
05
Safety considerations
Low off-tumor toxicityexpression heterogeneityantigen loss/immune escape
06
Interacting drugs
Racotumomab
3 more in the full profile.
07
Biomarkers
NGcGM3 expression on tumor cells for therapy selection and monitoring
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