Gap junction alpha-8 protein (GJA8 (Connexin-50; Cx50))

Gap junction alpha-8 protein is a member of the connexin family, forming hexameric connexons that dock between neighboring cells to create gap junction channels[2][3][6]. These channels facilitate the direct diffusion of ions, metabolites, and signaling molecules below 1 kDa, crucial for maintaining lens homeostasis and transparency[4][5][7]. GJA8 is highly expressed in the lens, and to a lesser extent in the cornea and other ocular tissues[7], and is essential for lens growth, fiber cell differentiation, and cell adhesion. Mutations cause a variety of inherited ocular disorders, often congenital and involving both lens structure and transparency. Genetic studies identify dominant, de novo missense, and microdeletion variants with variable penetrance and severity[5][7].

Other names

Connexin-50Cx50Lens fiber protein MP70CAECAE1CTRCT1CZP1MP70Gap junction alpha 8Gap junction membrane channel protein alpha-8Cell surface glycoproteinGap junction protein alpha 8 50kDaLens intrinsic membrane protein MP70

Drugs or antibodies targeting GJA8 affect gap junction channel formation and function, thereby modulating lens fiber cell communication and lens transparency.