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Gap junction gamma-1 protein (GJC1)
- Target
- GJC1
- Molecular classification
- Ion channel, Connexin family, Gap junction protein
01
Overview
Gap junction gamma-1 protein (GJC1), also known as connexin-45 (Cx45) or gap junction alpha-7 protein (GJA7), is a member of the connexin gene family that forms gap junction channels in cell membranes, enabling direct cell-to-cell communication by allowing diffusion of ions and small molecules (up to 1 kDa) between adjacent cells[1][3][4]. This protein is especially important in tissues requiring rapid electrical or metabolic coupling, such as the heart and nervous system, and plays a critical role in regulating physiological coordination at the multicellular level. Defects in GJC1 have been associated with disorders such as heart disease and oculodentodigital dysplasia[1][3][4].
- Other names
- Gap junction alpha-7 proteinConnexin-45Cx45CX45GJA7Gap junction protein, gamma 1, 45kDaGJC1CTC-296K1.4
02
Mechanism of action
Modulation of gap junction channel activity (for any therapeutic agents known to affect connexins generally; specific GJC1 modulators not indicated)
03
Biological functions
Intercellular communicationPassage of ions and small molecules between cellsRegulation of electrical and metabolic couplingSignal transduction
04
Disease associations
Cardiovascular diseaseHeart diseaseOculodentodigital dysplasia
05
Safety considerations
Potential arrhythmia or cardiac conduction disturbances if function is disrupted
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