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Target intelligence / Profile preview
Gap Junction Protein Alpha 1 (Cx43)
- Target
- Cx43
- Molecular classification
- Connexin, Gap Junction Protein
01
Overview
Gap junction protein alpha 1 (GJA1), also known as Connexin 43 (Cx43), is a member of the connexin family and a key component of gap junctions. These junctions facilitate direct communication between cells by allowing the passage of ions, metabolites, and signaling molecules. Cx43 is crucial for coordinated cellular responses across tissues, especially in the heart for electrical impulse propagation. Dysregulation of GJA1 is linked to various disorders including craniometaphyseal dysplasia and congenital heart disease.
- Other names
- Connexin 43GJA1CX43Cx43α1gap junction protein, alpha-like
02
Mechanism of action
Forms gap junction channels facilitating direct cell-to-cell communication.
03
Biological functions
Intercellular communicationElectrical impulse propagationExchange of ions and metabolitesCell differentiationCytoskeletal organization regulationCell migrationApoptosis inhibition
04
Disease associations
Craniometaphyseal DysplasiaCritical Congenital Heart DiseaseColobomaSkin diseasesBrain diseasesEar diseases
05
Safety considerations
Dysregulation can lead to congenital heart defectsPotential role in tumor development (context-dependent)Aberrant gap junction communication can disrupt tissue homeostasis
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