gap junction protein alpha 1 pseudogene 1 (GJA1P1)

GJA1P1 is a pseudogene associated with the GJA1 locus[1][3][5]. Pseudogenes are DNA segments similar in sequence to a known gene but typically lack protein-coding function, often due to mutations or truncations. The functional gap junction protein alpha 1 (GJA1, connexin 43) plays an essential role in forming gap junctions for cell-to-cell communication, especially in heart tissue and embryonic development[1][2][3][4][5]. GJA1P1, mapped to chromosome 5, does not produce functional protein and is not relevant as a therapeutic target. If your interest is in the active receptor/channel, refer to "gap junction protein alpha 1" (GJA1; CX43), a well-studied ion channel and drug target.