Gap junction protein beta 5 (GJB5 or Cx31.1)

Gap junction protein beta 5 is a member of the connexin family, encoded by the GJB5 gene, and also known as connexin-31.1 (Cx31.1)[3][1]. It forms transmembrane channels (gap junctions) which allow direct transfer of small molecules, ions, and signaling mediators between adjacent cells. These gap junctions are crucial for cell-to-cell electrical and metabolic communication, especially in the epidermis and various epithelial tissues[1][3][2][7]. Mutations in GJB5 can result in inherited skin disorders and have been linked to certain cancers, such as non-small cell lung cancer. The channel complexes formed by this protein are essential for tissue homeostasis, developmental processes, and environmental sensing[1][3]. While direct therapeutic targeting has not been established, its central role in disease highlights potential for drug development or biomarker use.

Other names

Connexin-31.1GJB5Cx31.1

Channel modulation (for hypothetical or future drugs, regulation of gap junction communication or blocking the channel)