Gap junction protein delta-4 (GJD4)

Gap junction protein delta-4 (GJD4) is a member of the connexin family of proteins that assemble to form gap junction channels, which create direct cytoplasmic connections between adjacent cells. Each gap junction channel is composed of two hemichannels (connexons), each made up of six connexin subunits such as GJD4. Through these channels, small molecules and ions (up to ~1 kDa) can diffuse, enabling the exchange of nutrients, metabolites, and signaling molecules between cells. GJD4 likely plays a role in modulating intercellular communication critical for functions like auditory signaling and may be involved in other physiological processes where gap junctions are essential. Deficiencies or mutations in connexin genes are known causes of diseases such as deafness and neuropathies, and while some disease associations exist for GJD4, functional and clinical relevance are still being elucidated.

Other names

Gap junction delta-4 proteinCX40.1Connexin-40.1connexin 40.1FLJ90023gap junction protein, delta 440.1kDa