GAR1 ribonucleoprotein (GAR1)

GAR1 ribonucleoprotein is a conserved, glycine- and arginine-rich nucleolar protein that forms part of the **H/ACA snoRNP complex**, which is essential for **rRNA pseudouridylation** and **ribosome biogenesis** in eukaryotic cells[3][4][7][1]. It facilitates substrate RNA placement, enhances the catalytic activity of Cbf5 (the pseudouridine synthase), and is necessary for the correct processing of pre-rRNA substrate and 18S rRNA formation[2][5][1]. GAR1 associates with other core proteins (NAP57/dyskerin/Cbf5, NHP2, and NOP10), and plays roles in telomerase holoenzyme assembly and function, with essentiality reflected by impaired cell growth in its absence[1][3][7][8]. GAR1's dysfunction is mapped to diseases involving ribosomal defects and telomerase activity, including Fanconi anemia and spinal muscular atrophy[3]. No known drugs interact directly with GAR1, nor is it a clinical biomarker or therapeutic target in current data.

Other names

Gar1p (in yeast)H/ACA ribonucleoprotein complex subunit 1GAR1