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Target intelligence / Profile preview
GARS1 divergent transcript (GARS1-DT)
- Target
- GARS1-DT
- Molecular classification
- Other (Long non-coding RNA)
01
Overview
GARS1 divergent transcript (GARS1-DT) is a long non-coding RNA located on chromosome 7 (gene symbol: ENSG00000196295), also known as AC005154.1 and AC005154.6. GARS1-DT has been identified as part of prognostic lncRNA risk signatures in clear cell renal cell carcinoma (ccRCC), where its expression is associated with patient survival outcomes. Functional studies link it to autophagy regulation, apoptosis, and response to hypoxic stress in cancer biology, but no direct targeting drugs or classical mechanisms of action are established. It is also being investigated as a prognostic biomarker in colorectal cancer.
- Other names
- AC005154.6AC005154.1GARS-DT
02
Mechanism of action
Not applicable. As an lncRNA, it does not encode a protein or have known small-molecule mechanisms of action
03
Biological functions
Regulation of autophagyRegulation of apoptosisInvolvement in cellular response to hypoxia
04
Disease associations
Cancer (notably clear cell renal cell carcinoma, also potential in colorectal cancer prognosis)
05
Safety considerations
None specifically reported for targeting GARS1-DT; lack of direct therapeutic development limits available data
06
Biomarkers
Risk score signatures in clear cell renal cell carcinoma (ccRCC)Possible prognostic marker in colorectal cancer
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