GAS6 antisense RNA 1 (GAS6-AS1)

GAS6 antisense RNA 1 is a long non-coding RNA gene located on chromosome 13q34. It is transcribed antisense to the GAS6 gene and acts through multiple molecular pathways to regulate cancer progression and cellular metabolism. GAS6-AS1 is upregulated in several cancers, supporting cell proliferation, invasion, and glycolysis, primarily by modulating signaling pathways such as AMPK/mTOR and acting as a competing endogenous RNA to sequester specific microRNAs. Downregulation of GAS6-AS1 has been shown to suppress tumor growth both in vitro and in vivo, suggesting potential as a therapeutic target and biomarker for patient prognosis[1][2][3]. Note: One key publication on clear cell renal cell carcinoma was retracted, so its conclusions should be interpreted with caution and require further independent verification[1]. Other cancer studies and genomic database entries confirm the existence, classification, and relevance of GAS6-AS1[2][3].

Other names

GAS6-AS1GAS6 antisense RNA 1HGNC: 39826NCBI Gene: 650669Ensembl: ENSG00000233695

Not applicable for drugs, but knockdown or silencing of GAS6-AS1 suppresses cancer cell growth and invasiveness, likely via: - Regulation of AMPK/mTOR signaling pathway - Regulation of miRNA (e.g., miR-215-5p) networks and downstream transcription factors (e.g., SOX9)