Gastric carcinoma proliferation enhancing transcript 1 (GHET1)

Gastric carcinoma proliferation enhancing transcript 1 (GHET1) is a long non-coding RNA highly expressed in gastric and multiple other human cancers. GHET1 does not encode a protein but exerts oncogenic functions largely by regulating gene expression post-transcriptionally—most notably by increasing c-Myc mRNA stability and expression through binding to IGF2BP1, which results in enhanced cancer cell proliferation, cell cycle progression, and inhibition of apoptosis. GHET1 upregulation is associated with tumor progression (including larger tumor size, invasion, metastasis, advanced stage) and poor prognosis in various malignancies. It functions in promoting cell proliferation, migration, invasion, and epithelial-mesenchymal transition. GHET1 is being evaluated primarily as a biomarker for cancer diagnosis, prognosis, and disease monitoring, but it is not currently considered a direct therapeutic target with any approved agents.

Other names

lncRNA-GHET1GHET-1gastric carcinoma highly expressed transcript 1gastric carcinoma high expressed transcript 1

Null (No known approved or in-trial drug targeting GHET1 directly. Research studies use siRNA-mediated knockdown for experimental inhibition, not a drug mechanism)