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Gastric Fundus Smooth Muscle
- Molecular classification
- Smooth Muscle Tissue
01
Overview
The gastric fundus smooth muscle refers to the specialized smooth muscle tissue located in the fundus, the upper part of the stomach. It plays a critical role in accommodating ingested food through receptive relaxation and regulating gastric motility through coordinated contraction and relaxation. Its function is modulated by neural, hormonal, and paracrine signaling pathways.
- Other names
- Fundus Smooth MuscleGastric Fundus SMCs
02
Mechanism of action
Varies depending on the drug. Cholinergics increase contractility. Nitric oxide donors and adenosine receptor agonists promote relaxation. ROCK inhibitors reduce contractile tone. Potassium channel openers modulate membrane potential.
03
Biological functions
Gastric AccommodationGastric MotilityGastric Emptying RegulationMixing of Gastric ContentsRegulation of Intragastric Pressure
04
Disease associations
Functional DyspepsiaGastroparesisGastric Motility Disorders
05
Safety considerations
Potential for drug interactions affecting gastric motilitySide effects associated with altering smooth muscle function
06
Interacting drugs
Cholinergics
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