Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Gastric H+, K+-ATPase (H+, K+-ATPase)
- Target
- H+, K+-ATPase
- Molecular classification
- Enzyme, Transporter, P-type ATPase
01
Overview
Gastric H+, K+-ATPase, also known as the gastric proton pump, is a membrane-bound enzyme complex responsible for acidifying the stomach contents by exchanging intracellular H+ for extracellular K+ using ATP hydrolysis. It is a key therapeutic target for managing acid-related disorders such as peptic ulcer disease and gastroesophageal reflux disease, and is inhibited by proton pump inhibitors (PPIs).
- Other names
- Hydrogen/potassium ATPaseGastric proton pumpProton pump
02
Mechanism of action
Irreversible inhibition of H+, K+-ATPase by covalent binding of PPIs to cysteine residues on the alpha subunit.
03
Biological functions
Acid secretionIon transportRegulation of gastric pH
04
Disease associations
Peptic ulcer diseaseGastroesophageal reflux disease
05
Safety considerations
Increased risk of infections (e.g., Clostridium difficile)Increased risk of osteoporosis and fractures with long-term useNutrient malabsorption (e.g., vitamin B12)Drug interactions
06
Interacting drugs
Omeprazole
5 more in the full profile.
Beyond the preview
Go deeper on Gastric H+, K+-ATPase (H+, K+-ATPase).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Gastric H+, K+-ATPase (H+, K+-ATPase).